The microbiology of neonatal sepsis in a rural Ecuadorian hospital
Abstract
Introduction: Neonatal sepsis continues to be a public health problem in Latin America. This study aims to describe the bacterial causes of early and late onset neonatal sepsis in a neonatal ICU in a rural hospital in Ecuador.
Methods: A descriptive, retrospective study was conducted using the hospital electronic medical record (EMR) from and all neonates diagnosed with neonatal sepsis were included in this study
Results: 74 neonates were included in the study. Seventeen (17) were characterized as neonatal sepsis within the first week of life (early onset neonatal sepsis) and 57 neonates were diagnosed as late onset neonatal sepsis. Staphylococcus epidermidis and Klebsiella pneumoniae were the most common cause of early onset and late onset neonatal sepsis, respectively.
Conclusions: The most common bacterial causes of neonatal sepsis in this study are distinct from those causes described in the United States. This could influence empiric initial antibiotic therapy decisions and other preventive measures if larger studies demonstrate similar results.
Downloads
References
2 Kim F, Polin RA, Hooven TA. Neonatal sepsis. Br Med J. (2020) 371:m3672. doi: 10.1136/bmj.m3672
3 Lawn JE, Blencowe H, Oza S, You D, Lee ACC, Waiswa P, et al. Every Newborn: Progress, priorities, and potential beyond survival. Lancet. (2014) 384:189–205. doi: 10.1016/S0140-6736(14)60496-7
4 Chaurasia S, Sivanandan S, Agarwal R, Ellis S, Sharland M, Sankar MJ. Neonatal sepsis in South Asia: Huge burden and spiralling antimicrobial resistance. Br Med J. (2019) 364:k5314. doi: 10.1136/bmj.k5314
5 Li J, Shen L, Qian K. Global, regional, and national incidence and mortality of neonatal sepsis and other neonatal infections, 1990-2019. Front. Public Health. (2023) 11:1139832.doi: 10.3389/fpubh.2023.1139832
6 Antibiotic regimens for early-onset neonatal sepsis. Korang SK, Safi S, Nava C, et al. Cochrane Database Syst Rev. 2021;5:0.
7 Pathophysiology of neonatal sepsis. Wynn JL, Wong HR. Fetal Neonatal Physiol. 2017;2:1536–1552.
8 Celik IH et al. What Are the Cut-Off Levels for Il-6 and Crp in Neonatal Sepsis? J Clin Lab Anal 24, 407–412 (2010).
9 Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study. Milton R, Gillespie D, Dyer C, et al. Lancet Glob Health. 2022;10:0–72.
10 Centers for Disease Control, USA: Early onset neonatal sepsis surveillance and trends. https://www.cdc.gov/abcs/reports/neonatal-sepsis.html
11 Dong Y, Speer CP. Late-onset neonatal sepsis: recent developments. Arch Dis Child Fetal Neonatal Ed. 2015 May;100(3):F257-63. doi: 10.1136/archdischild-2014-306213. Epub 2014 Nov 25. PMID: 25425653; PMCID: PMC4413803.
Copyright (c) 2024 Rural Family Practice

This work is licensed under a Creative Commons Attribution 4.0 International License.